![]() ![]() In the present report, we describe atypical CJD cases in a neurosurgeon and in a patient with a medical history of neurosurgery without dural grafting, showing the distinctive phenotypic features and transmission properties of plaque-type dCJD. For example, propagation of the second most common sporadic CJD strain (V2 strain) into codon 129 methionine homozygotes has been linked to plaque-type dura mater graft-associated CJD (dCJD), a subgroup of iatrogenic CJD with distinctive phenotypic features, but has never been observed in sporadic CJD. IMPORTANCE Susceptibility to and phenotypic expression of Creutzfeldt-Jakob disease (CJD) depend on both the prion strain and genotype at polymorphic codon 129 of the PRNP gene. Thus, careful analyses of phenotypic features and transmission properties in atypical cases may be useful to distinguish acquired from sporadic cases of CJD. These findings raise the possibility that the two cases, previously thought to represent sporadic CJD, might actually represent acquired CJD caused by infection with the V2 strain. In the present report, we describe atypical CJD cases carrying codon 129 methionine homozygosity, in a neurosurgeon and in a patient with a medical history of neurosurgery without dural grafting, showing the distinctive phenotypic features and transmission properties of plaque-type dCJD. In particular, the propagation of the V2 strain in codon 129 methionine homozygotes has been linked only to acquired forms of CJD such as plaque-type dura mater graft-associated CJD (dCJD), a subgroup of iatrogenic CJD with distinctive phenotypic features, but has never been observed in sporadic CJD cases. For example, while the most common sporadic Creutzfeldt-Jakob disease (CJD) subtype, sporadic CJD-MM1 (M1 strain), induces a single phenotype after experimental transmission regardless of the codon 129 genotype of the recipient animal, the phenotype elicited by sporadic CJD-VV2 (V2 strain), the second most common subtype, varies according to the host codon 129 genotype. I don't care what you think" "Watch it!" Cant Make out in England _ army, villainous force in Disney's "Mulan" Pot supporters Actor Armand _ "Beat it!" Attachment to Christ? Place to build a castle Fancy "I" Israeli leader with an eye patch Actress Gibbs of "The Jeffersons" Cubs' hangout Pastoral setting When a poser might be presented? Place for a stud Eager, informally Causes consternation Language of the Literature Nobelist Rabindranath Tagore Test in chemistry? "Yeah, I'm listening" Yellowstone attractions Bourbon relative Murphy's co-star in 1982's "48 Hrs.The genotype at polymorphic codon 129 of the PRNP gene has a profound influence on both phenotypic expression and prion strain susceptibility in humans. overseer "De-e-eluxe!" Elvis Presley sings it in "Blue Hawaii" Corpulence Tracking device Sells Some printers Facial piercing Place for free spirits Where the University of Wyoming is Contents of some towers, in brief Some sign language users In fact "Tough luck. worker Beheader of Medusa, in Greek myth One engaged in a struggle Need for translation, in biology Coined word in the title of 2008's Best Picture Congresswoman Demings Many mainframes Brewery stock Western city where copper-riveted jeans were invented Water nymph Big Ten football powerhouse, for short Big name in apple juice Dangerous thing to catch Two swings and a slide, maybe Do or _ (punny hair salon name) The Depression, for one Rally feature Team player who's not really a team player Wears Burning sensation Came to African antelope Group with the 2000 hit "This I Promise You" Website with the headings "Craft Supplies" and "Jewelry & Accessories" Cable channel owned by Discovery Convenient place to work out T.S.A. More answers for JanuSome internet humor It shares a key with a "3" Apple product launched in 2015 Vital hosp. ![]()
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